Effector and memory T cells

Regulatory T cells k

FIGURE 9-11 Biologic actions of IL-2. IL-2 stimulates the survival and proliferation of T lymphocytes, acting as an autocrine growth factor. IL-2 also maintains functional regulatory T cells and thus controls immune responses (e.g., against self antigens).

the properties and generation of regulatory T cells. An interesting feature of this function of IL-2 is that regulatory T cells do not produce significant amounts of the cytokine, implying that they depend for their survival on IL-2 made by other T cells responding to foreign antigens. • IL-2 has also been shown to stimulate the proliferation and differentiation of NK cells and B cells in vitro. The physiologic importance of these actions is not established.

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