Diseases Caused By Antibodies

Antibody-mediated diseases are produced either by antibodies that bind to antigens on particular cells or in extracellular tissues or by antigen-antibody complexes that form in the circulation and are deposited in vessel walls (Fig. 18-1). To prove that a disease is caused by antibodies, one would need to demonstrate that the lesions can be induced in a normal animal by the adoptive transfer of immunoglobulin purified from the blood or affected tissues of individuals with the disease. An experiment of nature is occasionally seen in children of mothers suffering from antibody-mediated diseases.

Mechanism of antibody deposition

Injury caused by antitissue antibody

^ Antibody vJp\ deposition 3ini (ci

Antigen in 1 extracellular matrix

Complement- and Fc receptor-mediated recruitment and activation of inflammatory cells

Enzymes, reactive oxygen species

Effector mechanisms of tissue injury

Neutrophils and macrophages

Neutrophils and macrophages

Complement- and Fc receptor-mediated recruitment and activation of inflammatory cells

Immune complex-mediated tissue injury

Blood vessel

Site of deposition of immune complexes

Circulating immune complexes

Complement- and Fc receptor-mediated recruitment and activation of inflammatory cells

Blood vessel

Site of deposition of immune complexes

Neutrophil granule enzymes, reactive oxygen species

Tissue injury |

Neutrophils

Neutrophils

Neutrophil granule enzymes, reactive oxygen species

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