Congenital abnormalities in the activation of T lymphocytes are being increasingly recognized as our understanding of the molecular basis of lymphocyte activation improves (Table 20-5). Included in this broad category are some disorders of CTL and NK cell granule composition or exocytosis. Although we classify disorders linked to defective MHC expression with disorders of T cell development, these abnormalities also result in defective activation of T cells that do mature and emerge from the thymus.
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