Cooh Tm

FIGURE 8-6 Domains of Ig and TCR proteins. The domains of Ig heavy and light chains are shown in A, and the domains of TCR a and P chains are shown in B. The relationships between the Ig and TCR gene segments and the domain structure of the antigen receptor polypeptide chains are indicated. The V and C regions of each polypeptide are encoded by different gene segments. The locations of intrachain and interchain disulfide bonds (S-S) are approximate. Areas in the dashed boxes are the hypervariable (complementarity-determining) regions. In the Ig m chain and the TCR a and P chains, transmembrane (TM) and cytoplasmic (CYT) domains are encoded by separate exons.

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