Hydrolysis and inactivation of C3b in fluid phase
C3b binds covalently to microbial surfaces, binds Factor B
Cleavage of Factor B by Factor D; stabilization by properdin
Fluid phase ^sv.hydrolysis
Cleavage of additional C3 molecules by cell-associated C3 convertase
C3b covalently binds to cell surface, binds to C3bBb to form C5 convertase i-
Cleavage of C5; initiation of late steps of complement activation
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