C3

C\C3a

Hydrolysis and inactivation of C3b in fluid phase

C3b binds covalently to microbial surfaces, binds Factor B

Cleavage of Factor B by Factor D; stabilization by properdin

Microbial surface

Fluid phase ^sv.hydrolysis

Cleavage of additional C3 molecules by cell-associated C3 convertase

C3b covalently binds to cell surface, binds to C3bBb to form C5 convertase i-

Cleavage of C5; initiation of late steps of complement activation

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