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FIGURE 8-10 V(D)J recombination. The DNA sequences and mechanisms involved in recombination in the Ig gene loci are depicted. The same sequences and mechanisms apply to recombinations in the TCR loci. A, Conserved heptamer (7 bp) and nonamer (9 bp) sequences, separated by 12- or 23-bp spacers, are located adjacent to V and J exons (for k and X loci) or to V, D, and J exons (in the H chain locus). The V(D)J recombinase recognizes these recombination signal sequences and brings the exons together. B, C, Recombination of V and J exons may occur by deletion of intervening DNA and ligation of the V and J segments (B) or, if the V gene is in the opposite orientation, by inversion of the DNA followed by ligation of adjacent gene segments (C). Red arrows indicate the sites where germline sequences are cleaved before their ligation to other Ig or TCR gene segments.

FIGURE 8-10 V(D)J recombination. The DNA sequences and mechanisms involved in recombination in the Ig gene loci are depicted. The same sequences and mechanisms apply to recombinations in the TCR loci. A, Conserved heptamer (7 bp) and nonamer (9 bp) sequences, separated by 12- or 23-bp spacers, are located adjacent to V and J exons (for k and X loci) or to V, D, and J exons (in the H chain locus). The V(D)J recombinase recognizes these recombination signal sequences and brings the exons together. B, C, Recombination of V and J exons may occur by deletion of intervening DNA and ligation of the V and J segments (B) or, if the V gene is in the opposite orientation, by inversion of the DNA followed by ligation of adjacent gene segments (C). Red arrows indicate the sites where germline sequences are cleaved before their ligation to other Ig or TCR gene segments.

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