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FIGURE 7-7 Binding of a TCR to a peptide-MHC complex. The V domains of a TCR are shown interacting with a human class I MHC molecule, HLA-A2, presenting a viral peptide (in yellow). A is a front view and B is a side view of the x-ray crystal structure of the trimolecular MHC-peptide-TCR complex. (From Bjorkman PJ. MHC restriction in three dimensions: a view of T cell receptor/ligand interactions. Cell 89:167-170, 1997. Copyright Cell Press.)

FIGURE 7-7 Binding of a TCR to a peptide-MHC complex. The V domains of a TCR are shown interacting with a human class I MHC molecule, HLA-A2, presenting a viral peptide (in yellow). A is a front view and B is a side view of the x-ray crystal structure of the trimolecular MHC-peptide-TCR complex. (From Bjorkman PJ. MHC restriction in three dimensions: a view of T cell receptor/ligand interactions. Cell 89:167-170, 1997. Copyright Cell Press.)

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