Opportunistic infections Protozoa (Toxoplasma, Cryptosporidium) Bacteria (Mycobacterium avium, Nocardia, Salmonella)

Fungi (Candida, Cryptococcus neoformans, Coccidioides immitis, Histoplasma capsulatum, Pneumocystis) Viruses (cytomegalovirus, herpes simplex, varicella-zoster) Tumors

Lymphomas (including EBV-associated B cell lymphomas) Kaposi's sarcoma Cervical carcinoma Encephalopathy Wasting syndrome

Although this summary of the clinical course is true for the most severe cases, the rate of progression of the disease is highly variable, and some individuals are long-term nonprogressors. The immunologic correlates of variable progression remain unknown. Also, recent anti-retroviral therapy has changed the course of the disease and greatly reduced the incidence of severe opportunistic infections (such as Pneumocystis) and tumors (such as Kaposi's sarcoma).

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