Non Invasive Methods to Measure the Blood and Myocardial Activity

Factor Analysis In the 1980's Factor Analysis (FA) was first used for nuclear medicine studies and subsequently applied to PET to generate cardiac blood and myocardial time activity curves in canine and human studies (14-17). Using this approach both curves are derived from dynamic images without the need to place regions of interest. The FA method is based on the principle that the intensity of a given image voxel is the linear superposition of counts from several compartments which represent...

Implementation of Correction Techniques in microPET

Random coincidences were initially measured by all microPET systems using the delay-window technique. Figure 11 Photographs of various microPET detectors. (A) Detectors of the prototype microPET (top) and microPET II (bottom). The MC-PMT in the prototype detector was much larger and required long optical fibers. microPET II detector uses fused optical fiber bundle, compact MC-PMT and 14 x 14 elements LSO array with sub-millimeter crystal width (as shown in C next to a penny). (B) Detector in...

References

Scanners get a fix in lab animals. Science 1999 286 2261-2262. 2. Paulus MJ, Sari-Sarraf H, Gleason SS. A new X-ray computed tomography system for laboratory mouse imaging. IEEE Trans Nucl Sci 1999 46 558-564. 3. Kujoori MA, Hillman BJ, Barrett H. High resolution computed tomography of the normal rat nephrogram. Invest Radiol 1980 15 148-154. 4. Sato T, Ikeda O, Yamakoshi Y, Tsubouchi M. X-ray tomography for microstructural objects. Appl Opt 1981 20 3880-3883. 5. Elliott JC, Dover...

MicroPET Technology

The prototype microPET scanner was developed by Cherry et al. 42 at UCLA in 1996. Its technology was made commercially available by Concorde Microsystems Inc., Knoxville, Tennessee, U.S.A. now part of Siemens Molecular Imaging in 2000. The second prototype system, microPET II, was completed in 2002 at UC Davis by the same group 49 , and the third generation microPET developed at Concorde was revealed in 2003 Focus 220 51 and 2004 Focus 120 52 . Figure 10 shows photographs of the micro PET...

Resolution Capabilities Of Microct

Although bench-top micro-CT scanners can achieve meaningful cubic voxel sizes as small as 5 im, the synchrotron radiation-based scanners provide the highest resolution, with voxels down to the submicrometer range. This is because of their brilliance and narrow bandwidth, energy-selective X-ray. Moreover, the synchrotrons generate X-ray intensity sufficiently high to permit rapid scanning 21 . An important contribution that micro-CT imaging can make to micro 3D imaging is that it can image...

Considerations In Radiation Catheter Design

Catheter design must consider diameter, flexibility, safety, and performance. The following section will review the potential detector materials that could be used in the intravascular environment i Gas-filled detectors e.g., ionization chambers ii Semiconductors e.g., cadmium telluride, lithium-drifted silicon, germanium , and iii Scintillators including organic liquid scintillators, solid crystals such as sodium iodide or bismuth germinate, and plastics . Most nuclear medicine imaging devices...