Probing Cellular Mechanical Responses to Stimuli Using Ballistic Intracellular Nanorheology

Lee,* Brian R. Daniels,* Thomas P. Kole,* Yiider Tseng,*'* and Denis Wirtz*'*' Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore, Maryland 21218 Department of Chemical Engineering University of Florida, Gainesville, Florida 32611 Department of Materials Science and Engineering The Johns Hopkins University Baltimore, Maryland 21218 Howard Hughes Medical Institute Graduate Training Program and Institute for...

Ax2t2 2RDrr

If the material is homogeneous and isotropic on length scales significantly smaller than the tracer, incompressible, and connected to the tracers by uniform no-slip boundary conditions over their entire surfaces, the two MSDs will be equal Ax2 t gt 2 Ax2 t gt . If these boundary and homogeneity conditions are not satisfied, the two MSDs will be unequal. In this case, applying the two-point MSD in the GSER will still yield the bulk rheology of the material on the long length scale R , while the...