Neovascularization is an important pathogenetic factor of myeloma. Increased bone marrow angiogensis correlates with disease progression.18 91-98 Vascular endothelial growth factor (VEGF) plays an important role in neovascularization of myeloma. It regulates endothe-lial cell function, vessel budding, and tube formation. In particular, it stimulates migration and proliferation of myeloma cells in an autocrine and paracrine loop.99
VEGF is produced by myeloma cells and BMCLs that are adhered to myeloma cells. It also augments the secretion of IL-6 by BMCLs.
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