Several reports of autologous hematopoietic stem cell transplantation for NHL have included patients with transformed lymphomas and have shown that prolonged remissions can be attained,27 73-75 although these reports have not always provided specific details on patients with transformed histology.

A retrospective study from the University of Nebraska compared outcomes following autologous stem cell transplantation of 10 patients with transformed lymphomas and 8 patients with follicular lymphomas.76 All patients with nontransformed lymphomas were alive between 246 and 1804 days following transplantation, while most of the patients with transformed lymphomas had early transplant-related deaths and only one was alive 99 days after transplant (P = 0.002). A retrospective analysis from France also examined outcomes of patients with follic-ular lymphoma following autologous stem cell trans-plantation.77 Overall survival of the 16 patients transplanted after histologic transformation was similar to that of 44 patients with follicular lymphoma; however, failure-free survival was significantly worse for patients

Table 67.3

Autologous hematopoietic stem cell transplantation for transformed

non-Hodgkin's lymphoma


No. of patients

Early mortality



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