Hematologic malignancies frequently present with symptoms due to absolute and/or functional thrombocytopenia. Currently, platelet transfusion remains the only proven method leading to rapid rise in platelet counts. The exact role and optimal dosing of the only approved platelet-lineage specific agent, IL-11, either in the prevention of the need for platelet transfusion or as a facilitator of platelet recovery, is unclear.89 Advanced clinical studies of thrombopoietin-like agents in patients with autoimmune thrombocytope-nia are in progress .

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