Presenting Features

Despite increasing awareness of this disease entity and advances in the diagnostic technology that have led to early diagnosis, the major presenting features in most patients remain remarkably consistent. Table 82.1 summarizes the initial findings in groups of patients seen at various periods of time in the last three to four decades.1-3 The findings in a small group of young and older patients are also included for comparison.4 5 The most frequent presentations are symptoms arising from myeloma involvement of bone and the bone marrow.

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