Symptoms referable to the eye, sinuses, orbit, ear, nose, or mastoid should be considered potential emergencies. Fulminant mucormycosis or aspergillo-sis may progress rapidly to the CNS. Sino-orbital infection (fungal or bacterial) may lead to orbital cel-lulitis, abscess, meningitis, or cavernous sinus thrombosis. Otologic infection may lead to progression of infection in the mastoid or temporal lobe. Rapid, surgical debridement, combined with highdose broad-spectrum therapy, represents the best chance for survival.
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