Monotherapy is used in a number of centers, and includes agents such as ceftazidime, cefepime, imipenem, or meropenem.13 Except for ceftazidime, these agents have Gram-positive as well as Gram-negative coverage. Advantages include a simpler regimen and less toxic-ity. Disadvantages include the risk of missing resistant organisms. Although randomized trials and meta-analyses have documented the efficacy of monotherapy,14 growing antimicrobial resistance may require reevaluation of this strategy in the future.13
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