Laboratory Abnormalities In Hyperleukocytosis

Pseudohyperkalemia can be present in patients with a high white blood count secondary to breakdown of white cells in vitro with subsequent release of potas-sium.2 Other spurious laboratory data that can be seen in association with hyperleukocytosis include a falsely elevated platelet count (secondary to white cell fragments), pseudohypoxemia (secondary to oxygen consumption by leukocyte cells), falsely prolonged coagulation tests, and pseudohypoglycemia.421-24 Pseudohypoxemia and pseudohypoglycemia can be avoided by placing samples on ice and performing tests immediately.4,14

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