As the therapy of chronic myelogenous leukemia (CML) has improved over the years, the definitions of response have changed. Before the recognition that allogeneic hematopoietic stem cell transplant (HSCT) could cure CML, the treatment of CML was palliative. Thus, remission meant that the blood counts were normalized and symptoms were controlled. This definition is inadequate today.
Table 20.1 lists the three categories of remission in CML, namely hematologic, cytogenetic, and molecular, as well as their most common definitions.
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