Clinical Presentation

The clinical presentation of CLL patients is diverse, with variability in presenting symptoms, physical examination findings, and laboratory test results. As noted above, patients often present without any symptoms, and the diagnosis is made on the basis of an elevated absolute lymphocyte count found on routine complete blood count (CBC). Less commonly, patients present with nontender lymphadenopathy, and are noted to have an elevated blood lymphocyte count on further evaluation. Some patients present with concomitant illnesses such as infection or chronic rhinitis, or less commonly, autoimmune phenomena such as autoimmune hemolytic anemia (AIHA) or immune thrombocytopenia purpura (ITP).

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