Antibody Recognition Of

Alloantibodies directed against determinants of allo-geneic HLA molecules can arise as a result of pregnancy, blood transfusion, and transplantation. Such antibodies are well known to cause rejection of solid organ transplants.51 The presence of patient antibodies against mismatched donor HLA antigens and a positive lymphocyte crossmatch is strongly associated with engraftment failure or graft rejection.52,53 For patients lacking an HLA-matched donor, recognizing the presence of HLA antibodies and defining the speci-ficity(ies) can be very important in finding compatible donors. Antibody reactivity and specificity can be determined by testing against panels of HLA-typed cells or purified HLA antigens.

Table 93.1

HLA ligands for inhibitory KIR

Inhibitory KIR

HLA ligand

Table 93.1

HLA ligands for inhibitory KIR

Inhibitory KIR

HLA ligand

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