Prognostic Relevance of Deletion 11q22q23

B-CLL cases with deletion 11q show more rapid progression of the disease and shorter survival times. In interphase FISH, deletion 11q22-q23 is the second most frequent aberration in B-CLL, with an incidence of approx 20%, and identifies a patient group with a characteristic clinical picture (26). B-CLL patients with 11q deletion present with advanced stages of disease and pronounced lymphadenopathy, reflected by large palpable peripheral, thoracic, and abdominal lymph nodes (Fig. 1). Moreover, patients with 11q deletion have a more rapid progression of disease, as measured by shorter therapy-free intervals (9 mo vs 43 mo; p < 0.001). In the survival time analysis, 11q deletion was associated with a poor prognosis, and the effect of this aberration on the course of the disease was age-dependent. In B-CLL patients younger than 55 yr, the survival time was significantly shorter in the group with 11q deletion than in the group without 11q deletion, whereas in patients 55 yr or older, there was only a trend to shorter survival times. Another, likewise age-dependent prognostic relevance was found in an examination of ATM protein expression in B-CLL (61). The poor outcome of B-CLL with 11q deletion was confirmed in an independent series (126). In multivariate analysis, 11q deletion was found to be an independent adverse factor (26). Since the 11q deletion appears to be prognostically relevant, especially in younger B-CLL patients, this aberration could serve to identify a patient group that could benefit from modern experimental strategies, such as autologous or allogeneic blood stem cell transplantation.

0 12 24 36 48 60 72 84 96 120 144 168

0 12 24 36 48 60 72 84 96 120 144 168

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