Water Deficit without Salt Deficit

When the ratio of dissolved solids (mostly salt) to water gets over a certain limit, we feel thirsty and we find something to drink, thereby diluting the concentration of dissolved solids back down to the desired level. At the same time, the brain releases a hormone called vasopressin or antidiuretic hormone that makes the kidney conserve water. But if there isn't much kidney function left, the organ can't respond to the hormone's chemical message. So although people with reduced kidney function can act on their thirst, they can't produce much concentrated urine.

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