Galanin is found throughout the CNS and enteric nervous systems. Three G protein-coupled receptors (GalR1-3) mediate the effects of galanin. Galanin causes inhibition of mechanosensitivity in 80% of mouse and 58% of ferret gastroesophageal afferents, respectively, whereas 12% displayed potentiated responses (181). The inhibitory effects are likely to be mediated via

GalR1 and/or 3 receptors and the potentiating effects via GalR2 receptors (181) based on their known coupling mechanisms.

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