It is becoming clear from the literature that visceral afferents represent a heterogeneous population of fibers that are individually tuned to detect distinct types of mechanical and or chemical stimuli by virtue of their location in the gastrointestinal tract. Different anatomical pathways may contain different classes of afferent fiber allowing for the specific detection and interpretation of certain stimuli. Moreover, the same class of afferent in different anatomical pathways is capable of responding with differing sensitivities, demonstrating the great detail in which mechanical and chemical events are signaled to the CNS.

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