Clinical Implications

The rapid effects of inflammatory mediators on ion channels sensitize neurons during inflammation. Blocking the formation and release of these substances through cyclo-oxygenase inhibitors reverses this process and decreases pain.

Serotonin plays a unique role in visceral sensation from the gastrointestinal tract. Serotonin release from enteroendocrine cells within the mucosa interacts with G-protein-coupled 5-HT receptors on afferent neurons and alters the properties of ion channels, including the TRPV1 receptor. Modulation of this heat- and proton-sensitive channel allows current flow and thus neuron activation at normal body temperatures, thereby contributing to symptoms in patients with functional diseases such as irritable bowel syndrome.

Was this article helpful?

0 0

Post a comment