Form Deprivation Myopia

Increased synthesis and accumulation of aggrecan, which increases the volume of extracellular matrix in the posterior sclera, are responsible for the ocular enlargement observed in form-deprived chick myopia (161). Synthesis of scleral proteoglycans including aggrecan is higher during the day than at night, but there are no significant differences between rhythms in scleras from normal and form-deprived eyes (162). The turnover rate of scleral proteoglycans is vision-dependent and is accelerated in the posterior sclera during the development of experimental myopia (163). Treatment with beta-xyloside, a specific inhibitor of proteoglycan synthesis, results in a significant reduction in the axial length, vitreous chamber depth and rate of axial elongation of form-deprived eyes (164).

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