Natural Supplements for Gastric Ulcer

Beat Ulcers

The system is all natural and easy to use. You are just minutes away from taking your first steps to having painless days and nights. In less than 2 weeks, you can be totally free from ulcers, living without the pain and feeling free to eat without the thought of pain. All you need do is follow the plan. Beat Ulcers is a step by step guide that shows you how you can eliminate ulcers in as little as 10 days. All you need do is use the readily available natural products in the correct proportions at the correct times. Here is what you will learn in the Beat Ulcers guide: How to Eliminate an Ulcer without the use of medication. How to rid your body of the ulcer causing bacteria and keep it away. How to stop the aching. How to eliminate the burping and bloating. Focus on the root cause of ulcers rather than the symptoms. How to be totally free from pain and sleep soundly at night. How to stop using dangerous medications that are prescribed over and over. Learn the causes of ulcers and how to eliminate them forever.

Beat Ulcers Summary

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Author: Tammy Myers
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The writer presents a well detailed summery of the major headings. As a professional in this field, I must say that the points shared in this book are precise.

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Peptic Ulcer

Peptic ulcers are small erosions in the wall of the stomach or duodenum. These areas are normally protected from gastric acid by mu-cosal secretions that form a protective barrier. When this barrier breaks down, damage occurs and an ulcer forms. Symptoms are pain, nausea, and bleeding. Ulcers are common, occurring in about one in 15 adults. The causes are multiple stress, poor diet, food sensitivities, and infection of the stomach by Helicobacter pylori can all contribute. Optimum nutrition can maintain the health of the protective lining of the stomach and duodenum. It can also support the immune system to increase resistance to chronic Helicobacter infection.

General Overdose Management

Gastrointestinal Increased gastric acidity leads to peptic ulcer, nausea and vomiting. Central nervous system (CNS) Agitation, restlessness, tremors, seizures. Metabolic Reduced serum K and Ca (chronic osteoporosis 2 cups day, 100 mg day). Muscle Increased contractility, high creatine phosphokinse (CPK), rhabdomyolysis.

Matrix Metalloproteinases

Matrix metalloproteinases (MMPs) are enzymes that induce degradation of extracellular matrix components. There are more than 20 types of MMPs, which are found in mammalian tissues and produced by different cell types. Each type of MMP can target one or more extracellular matrix components, although the activity of MMPs is not highly specific. Almost all MMPs are synthesized in cells as preproenzymes and released as inactive forms known as pro-MMPs. The inactive forms of MMPs can be activated by tissue and plasma proteinases or membrane-type MMPs (MT-MMPs), which cleave pro-MMPs. The production and activation of MMPs are highly regulated processes, which are critical to a number of physiological processes, including embryonic morphogenesis, neurite outgrowth, ovulation, bone growth, angiogenesis, apoptosis, and wound healing. In addition, MMPs are involved in the pathogenesis of a number of disorders, including cancer metastasis, atherosclerosis, skin ulceration, gastric ulcer, corneal...

CASE 2 Hypertension And Hypokalemia Case Description

His past medical history was otherwise notable for peptic ulcer disease, spastic colitis, frequent headaches, and a transient (5 min) episode of left-sided weakness at age 20 that spontaneously resolved. His family history was notable for a maternal grandmother who had hypertension and died of a cerebral hemorrhage at age 66. His mother also had hypertension, as did eight maternal uncles and aunts (all diagnosed in adulthood). He has one brother, 5 yr younger, who had started treatment for hypertension at age 23.

Diagnosis And Staging Of Gastric Malt Lymphoma

The most common presenting symptoms of gastric MALT lymphoma are dyspepsia, epigastric pain, nausea, and chronic manifestations of GI bleeding, such as anemia. The upper GI complaints often lead to an endoscopy that usually reveals nonspecific gastritis or peptic ulcer with mass lesions being unusual.41

Overall Market Size and Anticipated Growth

The efficiency of eradication of H. pylori infection (around 95-98 ) and the use of antibiotics have completely changed the approach to peptic ulcer therapy, significantly reducing the use of antisecretory compounds. Nonetheless, as shown in Table 1, antiulcer drugs represent the second most frequently sold drug class.

CAIs In The Alimentary Tract

Regulation of the acid-base balance in the alimentary tract is a physiological process involving a number of proteins, such as ion transport proteins, plasma membrane receptors and their ligands and CAs. Even though, or maybe because, several CA isozymes are involved in this process, applicability of CAIs has been so far limited in the gastrointestinal tract. Most attractive have been speculations that CAIs can be useful for the therapy of peptic ulcers. This was an early approach to attack the machinery of the acid-producing cell by acetazolamide (Baron 2000). In 1939, Davenport suggested that CA might be essential for acid production, and, consequently, an inhibitor of this enzyme would inhibit gastric acid secretion. A few years later, Davenport (1946) retracted this theory, because early inhibitors such as sulfanilamide failed to inhibit gastric acid secretion. Janowitz et al. (1952, 1957) demonstrated marked but very brief acid inhibition by acetazolamide and concluded that its...

Activity Efficacy and Safety of Corticosteroids in Palliative Treatment of Cancer Cachexia

Trial of Moertel et al. dates back to 1974 85 , and other important trials were published in the 1980s 86-89 , some considerations can be made approaching the results from an outcome point of view. All trials showed that corticosteroids (dex-amethasone or prednisolone, or methylpred-nisolone) induce a temporary benefit against different cachexia-related symptoms, improving the appetite, food intake, sensation of well-being, and performance status. Conversely, no trial demonstrated an improvement in body weight. Moreover, the trials of Robustelli della Cuna and Popiela 88, 89 approached the dimension of quality-of-life assessment during the treatment, and tried to go beyond symptom assessment in the outcome assessment in palliative care. Besides these interesting results detailed in Table 2, there is much evidence that corticosteroids can act against some other symptoms, that are related to, but not constitutive of, cancer cachexia, such as asthenia, or nausea and vomiting 90-93 . It...

Ion Channels Regulating Sensory Nerve Excitability Conduction And Transmission Sensory Neuron Specific Na1 Channels

Voltage-gated Na+ channels, composed of one pore-forming (-subunit and one or more auxiliary p-subunits, are crucial for neuronal excitability and propagation of action potentials (178,179). Among the 10 known a-subunits are two tetrodotoxin-resistant Na+ channels, Nav1.8 (previously termed SNS PN3) and Nav1.9 (SNS2 NaN) and one tetrodotoxin-sensitive Na+ channel, Nav1.7 (PN1), that are preferentially expressed by nociceptive DRG neurons (178182). Tetrodotoxin-resistant Na+ currents are also present in vagal and spinal afferent neurons supplying the rat stomach (183) and in DRG neurons projecting to the rat ileum and colon (127,184-186). There is mounting evidence that tetrodotoxin-resistant Na+ channels play a role in neuropathic and inflammatory hyperalgesia (178,179). Experimental gastritis and trinitroben-zene sulphonic acid (TNBSA)-induced ileitis enhance the excitability of DRG neurons predominantly via an increase of Nav1.8 currents (183,186,187). Similar alterations in vagal...

Bart L Clarke md and Sundeep Khosla md

Further evaluation showed that she had forearm osteopenia with a one-third distal radius bone mineral density (BMD) of 0.873 gm cm2 (T-score -1.8, Z-score -2.0), vertebral osteoporosis with an L2-L4 lumbar spine BMD of 0.650 gm cm2 (T-score -2.5, Z-score -2.0), and left femoral neck osteopenia with BMD of 0.755 gm cm2 (T-score -1.9, Z-score -1.5). An X-ray of the kidneys, ureters, and bladder with tomograms showed no calcium-containing kidney stones. She denied any complaint of abdominal pain, esophageal reflux, heartburn, or history of peptic ulcer disease. She complained of mild fatigue and difficulty maintaining concentration, and wondered whether her mild hypercalcemia was contributing to her lack of energy or declining mental acuity. Most patients currently diagnosed with primary hyperparathyroidism have asymptomatic mild hypercalcemia, typically with serum calcium levels less than 1.0 mg dL above the upper end of the normal range. More severe cases occasionally are diagnosed...

Current Treatment

Long before the mechanisms of activation of acid secretion by the stomach were recognized, extract of belladonna was found to ameliorate peptic ulcer symptoms. However, the active ingredient, atropine, has a generalized effect on all the muscarinic receptors in the body, resulting in side effects, such as blurred vision, dry mouth, and urinary tract dysfunction that resulted in abstinence from the drug. Even though atropine was later replaced by more selective M1 receptor antagonists (e.g., pirenzepine), the general muscarinic side effects, although reduced compared with atropine remained.19

Antiinflammatory Drugs and the

Local steroids are widely used in the treatment of eye disease systemic steroids are not used unless the sight of the eye is threatened. It must be remembered that systemic steroids give the patient a sense of well-being, which might give a false impression of the real benefit obtained. Furthermore, systemic steroids can have serious and life-threatening side effects, such as vertebral collapse through osteoporosis and perforated gastric ulcer (Figure 24.1).

Joseph B Muhlestein MD

Chronic infection has been found to be significantly associated with the development of atherosclerosis and the clinical complications of unstable angina, myocardial infarction, and stroke. A variety of infectious agents have been proposed to be involved in atherothrombosis, and, indeed, the number of implicated agents continues to increase each year. These include specific bacterial and viral agents, as well as a variety of agents associated with periodontal disease. However, failure to confirm initial reports of serological associations also has been common. The infectious agents with the most evidence to support an etiological role in atherosclerosis include Chlamydia pneumoniae and cytomegalovirus. In addition, evidence is mounting for a variety of other potential agents including other herpes viruses, influenza, other specific bacteria (such as Mycoplasma pneumoniae), and chronic infections with common bacterial agents (e.g., periodontal disease, chronic bronchitis, chronic...

Early Years

There was certainly no quantitative way of relating chemical properties to the biological properties. I began to wonder whether this pharmaceutical research could ever be as exciting again as I had found the research during my PhD years. Meanwhile SK& F moved out of London to Welwyn Garden City and then underwent an internal reorganization that brought in several scientists from ICI Pharmaceuticals. In particular James Black came in like a breath of fresh air to head Pharmacology and I instantly knew that here was somebody with whom I wanted to collaborate. Black initiated several lines of research but eventually all work was concentrated (because of limited resources) on to the search for compounds to block a new type of histamine receptor, the putative H2 receptor. This was a novel approach to controlling the secretion of gastric acid the therapeutic aim was to treat peptic ulcer disease. This was a real challenge for the medicinal chemists because there was no chemical lead...

Perioperative Pain

The principles of cancer pain management are now well established. The Cancer Pain Relief Program of the World Health Organization developed an analgesic ladder for the management of pain of increasing intensity (103). For mild pain, the recommendations start with NSAIDs. This drug class must be used with caution in those patients receiving steroids as part of their oncological management. NSAIDs are also contraindicated for patients who have renal insufficiency, intravascular volume depletion as seen with intractable vomiting, congestive heart failure, or peptic ulcer disease. A ceiling effect may occur, and increasing doses will lead to side effects without additional benefits. Unlike NSAIDs, opioids have no ceiling effect.

Dyspepsia

The previous section summarized the proportion of people who have symptoms of dyspepsia. However, these studies have not subjected these people to a diagnostic evaluation in order to determine whether or not they had functional dyspepsia. Many of these authors have, in fact, assumed that the majority of these people have functional dyspepsia. When determining the prevalence of functional dyspepsia, the investigators often exclude people who report a history of peptic ulcer disease, and approximately 8 of the population will report such a history (3,23). However, most people have not had any investigations and some people may report a history of peptic ulcer without having had any testing. Obviously, the absence of evaluation makes it very difficult to get a true estimate of the prevalence of functional dyspepsia. Still, the few studies that have evaluated people with dyspepsia in the community have not identified significant disease (24,29,30).

What Is Pain

The International Association for the Study of Pain (IASP) has defined pain as an unpleasant sensory and emotional experience associated with noxious stimuli or described in such terms (1). Implicit in this definition are two important features of pain. First and foremost is that pain is a perception that occurs in a conscious brain, requiring activation of multiple cortical areas to produce an experience. In contrast, nociception is the term used to describe activity in either the peripheral or the central nervous system (CNS) evoked by noxious stimuli. Importantly, nociception may or may not result in the perception of pain. The implication of this distinction is that pain not only requires consciousness, but also an intact nervous system and a nervous system that has developed sufficiently such that activity in subcortical nocicep-tive circuits is able to influence activity in the appropriate cortical circuits (2). Second, pain has both sensory and emotional content. This notion is...

Treatment of AAION

Elderly patients with arteritic disease have a high level of sensitivity to the side effects of these drugs. Particularly important in the initiation of treatment with high-dose corticosteroids is the unpredictable complication of acute psychosis, which can be potentially life threatening. It is a good practice to admit patients to hospital for at least the first 24 h of therapy, so that a complication of this sort will be noticed. Routine testing of the blood levels of glucose and electrolytes is always indicated. Prophylaxis for the prevention of osteoporosis and or gastric ulcer is always indicated as well. It is difficult to say for how long these precautions should be maintained. Recurrent disease more than 6 months after the initial diagnosis is rare, though possible. There have not been many reports of patients losing vision at these later stages of treatment. Any recurrence of ischemic neuropathy would be difficult to differentiate from the nonarteritic form. There is always a...

Hpi Pe

Primary hypersecretion of parathyroid hormone ijnay be caused by an adenoma (vast majority of cases), chief-cell hyperplasia, or carcinoma of the parathyroid glands it is commonly asymptomatic and is frequently recognized during routine physijcal exams. When it is symptomatic, peptic ulcer pain, polyuria, polydipsia, constipation, and pancreatitis may be the presenting symptoms. May be associated with multiple endocrine neoplasia (MEN) syndromes I and II.

The Stomach

Gastric pain is most often modeled using distension, chemical challenge, or both, of the stomach. Many different chemicals have been used to produce gastric damage, the most common of these employed in animal models of visceral sensory transduction being hydrochloric acid or acetic acid. Intragastric administration (using a feeding tube) of hydrochloric acid, at a concentration that will induce c-fos expression in the brainstem (0.5 M), causes writhing movements indicative of a noxious visceral insult with a peak response approximately 45 minutes after administration (18). Even so, only 42 (15 of 36) of rats that received the acid infusion responded in this way (a figure reported to be similar to the incidence of pain produced in humans following infusion of hydrochloric acid onto symptomatic peptic ulcers). Following the publication of methods by which acetic acid could be used to produce gastric ulceration (19,20) came the development of the kissing ulcer'' (21,22). This ulceration...

The Small Intestine

Figure 2 Acetic acid produces gastric ulcers in the rat. Kissing ulcers (A), induced in a rat three days after intraluminal application of 60 acetic acid. Arrows indicate round ulcers on the posterior and anterior walls. Using a different method (injection of 20 acetic acid into the stomach wall), the visceromotor response to gastric distension is significantly enhanced from three days (B) to 60 days (C) after acetic acid treatment (p< 0.05). Source (A) From Ref. 22 (B) Redrawn and adapted from Ref. 24. Figure 2 Acetic acid produces gastric ulcers in the rat. Kissing ulcers (A), induced in a rat three days after intraluminal application of 60 acetic acid. Arrows indicate round ulcers on the posterior and anterior walls. Using a different method (injection of 20 acetic acid into the stomach wall), the visceromotor response to gastric distension is significantly enhanced from three days (B) to 60 days (C) after acetic acid treatment (p< 0.05). Source (A) From Ref. 22 (B) Redrawn and...

Diet Gallstones

Fig. 5.4 Vitamin A as adjunctive therapy in gastric ulcer. 56 men with chronic gastric ulcers were given standard antacid therapy (in doses necessary to reduce stomach pain) or antacid therapy plus 150 000 lU day vitamin A for 4 weeks. Ulcer sizes, which did not differ between groups at the beginning of treatment, were reduced in both groups, but healing was significantly greater in the vitamin A group. Complete healing of ulcers occurred in 19 of men treated with antacids alone, compared with 39 from the antacids plus vitamin A group. (Adapted from Patty I, etal. Lancet. 1982 2 876) Fig. 5.4 Vitamin A as adjunctive therapy in gastric ulcer. 56 men with chronic gastric ulcers were given standard antacid therapy (in doses necessary to reduce stomach pain) or antacid therapy plus 150 000 lU day vitamin A for 4 weeks. Ulcer sizes, which did not differ between groups at the beginning of treatment, were reduced in both groups, but healing was significantly greater in the vitamin A group....

Historical Overview

The first H2 receptor antagonist developed was burimamide, followed by metiamide. With minimal structural alterations, Brimblecombe etal.3 developed cimetidine, the first 1 billion a year blockbuster drug (see 8.03 Medicinal Chemistry as a Scientific Discipline in Industry and Academia Personal Reflections). The modification of the chemical structure of cimetidine, with elimination of the imidazole ring, led to ranitidine, the pharmacokinetic characteristics of which provided improved patient compliance. These drugs provided effective inhibition of production and release of gastric acid via a pharmacologically proven mechanism, and became the gold standard therapy for peptic ulcers during the 1980s, leading to a marked improvement in the quality of life for a large number of patients, and substantial reductions in the societal costs of the treatment and incapacitation associated with gastric ulceration. These shortcomings were overcome with the discovery and development of proton pump...

Helicobacter Pylori

Over the past decade or so H. pylori has been shown to play a causative role in gastric inflammation and peptic ulcer disease. Its role has been established because the presence of infection is a risk factor for the development of ulcers ulcers do not develop in the absence of infection, except when other known etiological factors exist, such as the use of nonsteroidal anti-inflammatory drugs care of the infection results in a dramatic drop in the rate of ulcer relapse, from 80 to 15 in the first year, with even lower rates thereafter and experimental infection of gerbils and mice causes gastroduodenal injury. Gastric infection with H. pylori is also found to be associated with the development of stomach cancer.