Fluorinated Functions And Motifs In Medicinal Chemistry

In most of cases, the fluorine atom(s) or the CF3 group(s) is borne by aromatic rings. Synthesis of these compounds for the optimization of hits as well as for parallel synthesis is done using the numerous fluoro aromatic or heterocyclic compounds that are commercially available. These latter compounds generally come from aromatic fluoridation or trifluoromethylation reactions (especially the Balz-Schiemann reaction) and from heterocyclization reactions. However, fluoroaliphatic chains and...

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Figure 8.60 Cholesterol transport protein inhibitor. 8.5.1.2 Cholesterol Transport Protein Inhibitor Ezetimibe is the first hypolipidemic agent to act by blocking the absorption of dietary cholesterol at the intestinal level. It represents a novel treatment option for patients with hypercholes-terolemia, alone or in combination with statins (Figure 8.60). 8.5.1.3 Cholesteryl Ester Transfer Protein Inhibitors Cholesterol ester transfer protein (CETP) is a glycoprotein that transfers cholesteryl...