Toxicity

Toxic cataracts are probably rare, although several currently used drugs have been incriminated, the most notable being systemic steroids. Chlorpromazine has also been shown to cause lens opacities in large doses, and so has the use of certain meiotics, including pilocarpine. Much of our knowledge of drug-induced cataracts is based on former animal experiments. The potential danger of new drugs causing cataract was shown in the 1930s after the introduction of dinitrophenol as a slimming agent. This produced a large number of lens opacities before it was eventually withdrawn.

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