This is the "photographic film" of the eye that converts light into electrical energy (transduc-tion) for transmission to the brain. It consists of two main parts:
1. The neuroretina - all layers of the retina that are derived from the inner layer of the embryological optic cup.
2. The RPE - derived from the outer layer of the optic cup. It is comprised of a single layer of cells, which are fixed to Bruch's membrane. Bruch's membrane separates the outer retina from the choroid.
The retinal photoreceptors are located on the outer aspect of the neuroretina, an arrangement that arose from inversion of the optic cup and allows close proximity between the photosensitive portion of the receptor cells and the opaque RPE cells, which reduce light scattering. The RPE also plays an important role in regeneration/recycling of photopigments of the eye and during light-dark adaptation.
In order for the light to reach the photo-receptors to form sharp images, all layers of the retina inner to the photoreceptors must be transparent. This transparency is contributed to by the absence of myelin fibres from the retinal neurons. The axons of the retina ganglion cells normally become myelinated only as they pass through the optic disc to enter the optic nerve.
There are two main types of photoreceptors in the retina - the rods and the cones. In the fovea centralis the only photoreceptors are cones, which are responsible for acute vision (visual details) and colour vision. Outside the fovea, rods become more abundant towards the retinal periphery. The rods are responsible for vision in poor (dim) light and for the wide field of vision.
The retinal capillary network (derived from the central retinal artery) extends no deeper than the inner nuclear layer and nourishes the neuroretina from inside up to part of the outer plexiform layer. It is an end-arterial system. The choroid serves to nourish the RPE and the photoreceptors (by diffusion of nutrients). There are no blood vessels in the outer retina. The central fovea is completely avascular and depends on diffusion from the choroidal circulation for its nourishment. Thus, normal functioning of the retina requires normal retinal and choroidal circulation.
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