Mitochondrial Inheritance

Mitochondria are the only organelles of the cell besides the nucleus that contain their own DNA. They also have their own machinery for synthesising RNA and proteins. Instead of individual chromosomes, mitochondria contain circular DNA similar to bacteria (from which they are thought to be derived). Mitochondrial DNA contains 37 genes,predominately encoding the enzymes necessary for the respiratory chain. All mitochondria in the zygote are derived from the ovum; therefore, a mother carrying a mitochondrial DNA mutation will pass it on to all of her children (maternal inheritance) but only her daughters will pass it on to their children. Mito-chondrial DNA mutations are usually manifest clinically in tissues with a high metabolic demand, for example brain, nerve, retina, muscle and renal tubule. Examples of ophthalmic diseases caused by mitochondrial DNA mutations include Leber's hereditary optic neuropathy, chronic progressive external ophthal-moplegia, maternally inherited diabetes and deafness, and Kearns-Sayre syndrome.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment