This term means "white pupil" and it is an important sign in childhood. There are a number of conditions that can produce this effect in early childhood. The important thing to realise is that if a mother notices "something white" in the pupil, the matter must never be overlooked and requires immediate investigation. The differential diagnosis includes congenital cataract, opaque nerve fibres in the retina, retinopathy of prematurity, endophthal-mitis, some rare congenital abnormalities of the retina and vitreous and, not common but most important, retinoblastoma.

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