Table 2 A selection of hydrolases EC 3 with known or potential activity toward xenobiotic substrates6

EC 3.1 Acting on ester bonds EC 3.1.1 Carboxylic ester hydrolases

EC 3.1.2 Thiolester hydrolases

EC 3.1.3 Phosphoric monoester hydrolases

EC 3.1.4 Phosphoric diester hydrolases EC 3.1.6 Sulfuric ester hydrolases

EC 3.1.7 Diphosphoric monoester hydrolases

EC 3.1.8 Phosphoric triester hydrolases

EC 3.2 Glycosylases

EC 3.2.1 Glycosidases, i.e., enzymes hydrolyzing O- and S-glycosyl compounds

EC 3.2.2 Hydrolyzing N-glycosyl compounds

EC 3.3 Acting on ether bonds EC 3.3.2 Ether hydrolases

EC 3.4 Acting on peptide bonds (peptidases) EC 3.4.11 Aminopeptidases

EC 3.4.13 Dipeptidases

EC 3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

EC 3.4.16 Serine-type carboxypeptidases EC 3.4.17 Metallocarboxypeptidases

EC 3.1.1.1 Carboxylesterase

EC 3.1.1.2 Arylesterase

EC 3.1.1.6 Acetylesterase

EC 3.1.1.7 Acetylcholinesterase

EC 3.1.1.8 Cholinesterase

EC 3.1.1.10 Tropinesterase

EC 3.1.1.13 Sterol esterase

EC 3.1.1.55 Acetylsalicylate deacetylase

EC 3.1.1.60 Bis(2-ethylhexyl)phthalate esterase

EC 3.1.1.67 Fatty-acyl-ethyl-ester synthase

EC 3.1.2.1 Acetyl-CoA hydrolase

EC 3.1.2.2 Palmitoyl-CoA hydrolase

EC 3.1.2.3 Succinyl-CoA hydrolase

EC 3.1.2.7 Glutathione thiolesterase

EC 3.1.3.1 Alkaline phosphatase

EC 3.1.3.2 Acid phosphatase

EC 3.1.4.1 Phosphodiesterase I

EC 3.1.6.1 Arylsulfatase

EC 3.1.6.2 Steryl-sulfatase

EC 3.1.7.1 Prenyl-diphosphatase

EC 3.1.7.3 Monoterpenyl-diphosphatase

EC 3.1.8.1 Paraoxonase

EC 3.1.8.2 Diisopropyl-fluorophosphatase

EC 3.2.1.20 a-Glucosidase EC 3.2.1.21 ß-Glucosidase EC 3.2.1.31 ß-Glucuronidase

EC 3.2.2.1 Purine nucleosidase

EC 3.3.2.3 Epoxide hydrolase

EC 3.4.11.1 Leucyl aminopeptidase

EC 3.4.11.2 Membrane alanyl aminopeptidase

EC 3.4.11.3 Cystinyl aminopeptidase

EC 3.4.11.5 Prolyl aminopeptidase

EC 3.4.11.6 Arginyl aminopeptidase

EC 3.4.11.7 Glutamyl aminopeptidase

EC 3.4.11.15 Lysyl aminopeptidase

EC 3.4.11.17 Tryptophanyl aminopeptidase

EC 3.4.11.18 Methionyl aminopeptidase

EC 3.4.11.19 d-Stereospecific aminopeptidase

EC 3.4.11.21 Aspartyl aminopeptidase

EC 3.4.11.22 Aminopeptidase I

EC 3.4.13.18 Cytosol nonspecific dipeptidase

EC 3.4.13.19 Membrane dipeptidase

EC 3.4.13.21 Dipeptidase E

EC 3.4.14.1 Dipeptidyl-peptidase I

EC 3.4.14.2 Dipeptidyl-peptidase II

EC 3.4.14.4 Dipeptidyl-peptidase III

EC 3.4.14.5 Dipeptidyl-peptidase IV

EC 3.4.16.2 Lysosomal Pro-Xaa carboxypeptidase

EC 3.4.16.5 Carboxypeptidase C

EC 3.4.16.6 Carboxypeptidase D

EC 3.4.17.1 Carboxypeptidase A

EC 3.4.17.2 Carboxypeptidase B

Table 2 Continued

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