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Biography

William F Trager is currently Emeritus Professor of Medicinal Chemistry of the School of Pharmacy, University of Washington, Seattle, Washington. He is a naturalized citizen from Winnipeg, Canada. In 1960, he received his BS in Chemistry from the University of San Francisco, San Francisco, California and in 1965 his PhD in Medicinal Chemistry from the University of Washington under the direction of Professor Alain C Huitric working in the area of conformational analysis using NMR. After receiving his PhD, he spent 2 years as a Postdoctoral Fellow with Professor Arnold H Beckett at the Chelsea School of Science and Technology in London, England. His postdoctoral studies involved the structural analysis of mitragyna alkaloids of unknown structure by spectral means (NMR, CD, IR, and UV).

In 1967 Dr Trager joined the faculty of the School of Pharmacy, University of California at San Francisco as an Assistant Professor of Medicinal Chemistry. While at the University of California he was responsible for the High Resolution Mass Spectral Facility and developed his on-going interest in drug metabolism. In 1972 he returned to the University of Washington as an Associate Professor of Medicinal Chemistry. In 1977 he was promoted to full Professor and received a Career Development Award from the National Institutes of Health. In 1978 spent 3 months at the NIH working in the Laboratory of Chemical Pharmacology with Dr James Gillette. In 1980 he was appointed as Science Advisor to the FDA, Seattle District, Chairman of the Department of Medicinal Chemistry in the School of Pharmacy and Adjunct Professor of Chemistry in the Department of Chemistry. In 1984 he left the Chair and returned to his academic positions. From 1983 to 1987, Dr Trager served as a committee member of the Pharmacological Sciences Review Committee of the National Institutes of General Medical Sciences and in subsequent years he frequently served as an ad hoc member of various study sections and site visit teams.

Dr Trager's primary research interests are in drug metabolism and he was the P.I. of an NIH Program Project Grant for the past 20 years investigating the molecular basis of the phenomena of drug interactions. More specific interests include quantitative mass spectrometry using stable isotopes, stereoselective metabolism, and the use of deuterium isotope effects to study mechanisms of cytochrome P450-catalyzed reactions and active site structure. In 2004 Dr Trager retired from the University and was converted to Emeritus status.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medicinal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 5) 0-08-044518-7; pp. 87-132

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