R

Figure 12 Structure of the cofactor 3'-phosphoadenosine 5'-phosphosulfate (29; PAPS); generic reactions of N-sulfation

SULT3, which is involved in amine sulfation and should correspond to amine sulfotransferase (EC 2.8.2.3). However, there are marked and condition-dependent overlaps in the substrate specificity of all these sulfotransferases, a fact that prevents any strong and one-to-one correspondence between the IUBMB and the homology-based nomenclatures. Nevertheless, it is well established that the enzymes of greatest significance in the sulfation of xenobiotics are the aryl sulfotransferases, the alcohol sulfotransferases, and the amine sulfotransferases.

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