Monoamine Oxidases

Monoamine oxidases (MAO, EC 1.4.3.4) are FAD-containing flavoproteins, recognized primarily for their physiological role in metabolically regulating levels of neurotransmitters in the brain. Unlike FMO, the FAD group functions only as an electron acceptor (FAD-FADH2) during oxidative deamination of these biogenic amines. In addition to its physiological role, MAO can participate in the metabolism of certain xenobiotics, especially drug molecules that are structurally related to the endogenous substrates.52

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