Figure 4 Time course of the plasma concentration of a drug administered by the extravascular route. The same data are displayed as linear (LIN/LIN) and semilogarithmic (LIN/LOG) plots. Dose: 5mg, Cmax: 30 mgL~1, AUC: 420h mgL~1, and f1/2 8h. No lag time is observed here.

The AUC (area under the curve of a plasma concentration versus time profile) from time 0 to the last sampling is calculated directly from concentrations C and their corresponding t by using eqn [10] (trapezoidal rule):

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