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Urine: drug & metabolites

Figure 2 Equilibria between blood and various organs, with liver and kidneys as excretion pathways. It is assumed that each binding is governed by a reversible equilibrium. At any one time, the free drug concentrations are assumed to be rapidly exchangeable. The liver (by biotransformation and bile excretion) and kidneys (by urine excretion) continuously disrupt the general equilibrium by removing some of the free drug. At steady-state, the free drug concentration is assumed to be identical in plasma and organs.

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