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Table 2 Major human P450 drug-metabolizing enzymes with their most common diagnostic substrates and inhibitors

Isoform (pmol [mg prot] 1)

Typical substrate

Typical inhibitor

1A2 (10-50)

Theophylline

Furafylline2

2A6 (0-20)

Coumarin

(R)-Tranylcypromine

2B6 (0-50)

Bupropion

Thiotepa, Clopidogrel

2C8 (10-25)

Taxol, amodiaquine

Montelukast

2C9 (40-80)

(S)-Warfarin

Sulfaphenazole, benzbromarone

2C19 (0-30)

(S)-Mephenytoin

(R)-Benzylphenobarbital1

2D6 (0-15)

Dextromethorphan

Quinidine

2E1 (10-50)

Chlorzoxazone

Disulfiram (diethyldithiocarbamate)

3A4 (50-350)

Midazolam

Ketoconazole, troleandomycin

Parentheses indicate typical hepatic microsomal concentration ranges.

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