The extrapolation to infinite may be done as per eqn [11]:

AUC is expressed as time multiplied by concentration. When the kinetics is linear, AUC is proportional either to the amount of drug that reaches the body without any transformation, or to the amount of metabolite when its concentrations have been measured.

The total plasma clearance indicates the elimination of the drug from the body whatever the process involved (metabolism, urinary excretion, bile secretion, pulmonary elimination).14 It is the part of the distribution volume (VD) cleared by time unit (eqns [12-15]).

CL = Vd amount of drug metabolized and/or excreted per unit of time amount of drug in the body dM/dt dM/dt

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