Info

Cynomolgus monkey feces, 0-24 h pool tJluJ^i

Parent

I 1 I 1 I 1 I 1 I 1 I 1 I 1 I 1 I 1 I 1 I 0 5 10 15 20 25 30 35 40 45 50

(a) Retention time (min)

Human feces, 0-24 h pool

Parent i 1 i 1 i 1 i 1 i 1 i 1 i 1 i 1 i 1 i 1 i 0 5 10 15 20 25 30 35 40 45 50

Retention time (min)

Figure 1 Metabolite patterns in plasma and feces collected from cynomolgus monkey (a) and human (b) excretion balance studies. The identity of parent drug and metabolites A, B, C, and D were confirmed by LC/MS/MS analysis.

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