Hydrolytic reactions in drug metabolism are commonly catalyzed by esterases, amidases, phosphatases, and epoxide hydrolases. While these reactions appear initially quite diverse, in fact each of these enzymes is linked structurally, by membership in the a/b hydrolase-fold family of proteins, and mechanistically, by their reliance on a 'catalytic triad' of acidic and basic residues to effect hydrolysis.83 Peptidases are not addressed in this chapter but are discussed in depth in 5.06 Principles of Drug Metabolism 2: Hydrolysis and Conjugation Reactions and a recent book.84

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