Glutathione S-transferase (GST, EC 220.127.116.11) enzymes catalyze conjugation of xenobiotics and endogenous compounds with reduced GSH. Two superfamilies of GST proteins are recognized. Membrane-associated proteins involved in eicosanoid and GSH metabolism (MAPEG) family members are involved in several important physiological processes, including the synthesis of peptido-leukotrienes and the 5-lipoxygenase pathway, but do not seem to have a role in xenobiotic metabolism. Conversely, the cytosolic GSTs (cGSTs) metabolize a wide range of environmental agents and numerous drugs.121 cGSTs have a particularly important toxicological role in scavenging reactive electrophilic species generated within the cell by various processes, and a large body of literature exists on the role of cGSTs in cancer.122
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