Figure 6 Topological models of the human SLC22; (a) organic cation transporters (OCT), organic anion transporters (OAT), and SLCO; (b) the organic anion polypeptide transporter (OATP). Features common to all members of the OCT, OAT, OATP transporter family include 12 transmembrane-spanning domains (TMDs) with intracellular amino and carboxyl termini. Transmembrane a-helical domains (TMD) indicated by red rectangular bars; N-glycosylation sites (indicated by branches ) are present on extracellular protein loops. Cytoplasmic (in) and extracellular (out) orientations are indicated.
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