Carbonyl Reductases CBRs

CBRs are a subset of short-chain dehydrogenase/reductases242'243 that belong to a superfamily of oxidoreductases.244 They are found in cytosol, have broad substrate selectivity, and encompass both endobiotic and xenobiotic carbonyl compounds, including prostaglandins, steroids, and quinones, plus a wide array of aromatic and aliphatic aldehydes and ketones. For recent reviews, see Oppermann and Maser235 and Rosemond and Walsh.245 Typical examples of CBR-catalyzed reduction of quinone carbonyls or keto groups contained in a xenobiotic include the reduction of the anthracycline antibiotic doxorubicin (2 19),246 halopyridol (220),247 metyrapone (221),247 acetohexamide (222),247 and warfarin (223).248

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