Suprabasilar Vesicles

Synonym: Hailey-Hailey disease

Clinical Presentation:

■ Recurrent vesicles and erosions involving flexural areas, particularly the axillae, groin, inframammary folds, and neck (Fig. 6A)

■ Signs may appear for the first time from late teens to the third or fourth decades

■ Disease is generally of relatively limited extent; however, widespread involvement can occur

Histology (Fig. 6B):

■ Hyperkeratosis

■ Acanthosis

■ Partial acantholysis of spinous layer of epidermis

■ "dilapidated brick wall"

■ Suprabasilar clefts

■ Perivascular infiltrate of lymphocytes and eosinophils

Immunofluorescence Studies:

Clinicopathologic Correlation:

Clinical Feature

Histologic Feature

Crusted plaques

Hyperkeratosis and acanthosis

Erosions

Acantholysis throughout the epidermis

Differential Diagnosis:

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