Spongiotic Dermatoses

Clinical Feature

Pathologic Feature

Vesicle or bulla

Marked epidermal spongiosis

Scale

Orthokeratosis and parakeratosis

Crust

Serum, red blood cells, and debris on surface

Thin plaque

Mild to moderate acanthosis

Thick, lichenified plaques

Marked acanthosis and dermal fibrosis

Table 4 Histologic Differential Diagnosis: Allergic Contact Dermatitis

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