Spongiotic Dermatitis

Spongiotic dermatitis is a histologic rather than a clinical diagnosis that is characterized by intraepidermal, intercellular edema (spongiosis) with or without microvesicle formation.

Table 4 Differential Diagnosis: Benign Familial Pemphigus

Benign Familial Pemphigus

Keratosis Follicularis

Pemphigus

Transient Acantholytic Disease

Thick hyperkeratosis

Acantholytic dyskeratosis; corps

Stratum corneum relatively normal

Focal hyperkeratosis

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