■ Genodermatosis of autosomal dominant inheritance produced by abnormalities in desmosomal adhesion between keratinocytes. ATP2A2 has been identified as the causative gene for keratosis follicularis.
1. Kosann MK. Keratosis follicularis. Dermatol Online J 2003; 9:35.
2. Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darir's disease and Hailey-Hailey disease. Br J Dermatol 2004; 150:821-828.
3. Sehgal VN, Srivasrava G. Darier's (Darier-White) disease/kera-tosis follicularis. Int J Dermatol 2005; 44:184-192.
TRANSIENT ACANTHOLYTIC DERMATOSIS (FIG. 11)
Synonym: Grover's disease. Clinical Presentation:
■ Pruritic, papular, and vesicular eruption typically occurring on the trunk
■ More common in middle-aged and elderly individuals, particularly males
■ Predominantly self-limited but may pursue a chronic course
■ Focal changes
■ Mild epidermal hyperplasia
■ Four patterns within the epidermis that may occur independently or intermixed:
■ Pemphigus pattern with suprabasilar acantholysis
■ Familial pemphigus pattern with partial acantholysis
■ Keratosis follicularis pattern with corps ronds and corps grains
■ Spongiotic pattern
See "Differential Diagnosis" table under section "Keratosis Follicularis."
The etiology is unknown, but excessive ultraviolet light exposure, heat, sweating, and ionizing radiation have been linked to the disease.
1. Davis MD, Dinneen AM, Landa N, Gibson LE. Grover's disease: clinicopathologic review of 72 cases. Mayo Clin Proc 1999; 74:229-234.
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