Info

Inflammatory infiltrate is deep and

Inflammatory infiltrate is limited to

often periadnexal

superficial dermis

Focal parakeratosis may be present

Parakeratosis is not a feature

Immunohistochemistry:

■ Large, atypical lymphocytes within the dermal infiltrate are CD30+ (Ki-1), CD3+, and CD15-.

■ All CD30+ cells are anaplastic lymphoma kinase (ALK)-negative.

Pathophysiology:

■ Lymphomatoid papulosis is a lymphoproliferative disorder representing a clonal expansion of CD30+ T cells with a common rearrangement in the T-cell receptor(TcR) gene

Differential Diagnosis:

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